In my experience, they will be no different. I've planted 2yr root in beds where seedlings were harvested several years prior. I think only two lived and I don't know if they came back the second year.
My recommendation is to get the area you want to seed ready by clearing undergrowth and trimming tree branches up until you can walk under them. This helps with airflow also. Then plant in a rough 8 x 12 spacing dropping a couple seeds at a time. Then, in two years, go back and seed over the same area again in maybe a 12 x 12 right over seedlings that are there. If you seed earlier in the fall you can see where the bare spots are in seed those thicker. When I seed with the seeder I don't spend time worrying about spacing at all. I plant in a semi-circle in front of me (right handed and go from right to left) and move the seeder over about 8 inches or so each time I poke a hole. Then, when I get to my left side, I take a small step forward and start again.
Seeding the same patch again does two things. First, it allows you to fill in where the plants didn't make it. Secondly, it gives you mixed age classes at harvest. This can be important.
By using this method, you will have seedlings you didn't plant start showing up about year 6 on their own given you have a good location. So if you are with me so far, we have a naturally reproducing patch of ginseng. I've never seen replant failure in wild patches when planted seed from plants I've harvested. So my recommendation is to only SELECTIVELY HARVEST the biggest plants which have attained the age, size and shape characteristics to bring the highest market prices.
Lets do the math just for giggles. (this is theoretical of course no guarantees are being made here to anyone

)
43,560 square feet in an acre. If we go with 6x6 spacing, that is about 5 per square foot which is generally considered max for wild sim sustainability (and the numbers are easier to work with here in this example). Because of rocks and trees, lets go with 80% plantable. So we have 43,560 x .8 =34,848 square feet x 5 seeds per foot = 174,240 / 7000 seeds per pound = 24.89 lbs of seed.
Now, if only 20% of those 174,240 seeds grow and survive to 10 years, that would be 174,240 x .2 = 34,848 10 year old plants. Of those 34,848 plants, I would guess only about 40% of those will be of harvestable size or quality. So, 34,848 x .4 = 13,939 plants. If we say that harvestable is 150 roots/lb, then 13,939 / 150 = 92.92 lbs of ginseng to harvest.
You won't be able to dig 93 lbs in a season if you are digging it carefully for top dollar. You are much better off selectively harvesting only the biggest and best quality, digging them very carefully as individuals and bringing the highest quality root to market. This way, you do not tear up the whole patch. The roots you did not dig this year will be getting bigger and older for next year and will hopefully still be producing seed to continue the patch.
Also, by selectively harvesting a single root at a time, I think you will avoid the replant failure issue all together.
I've a patch ready to harvest, but have held off the past couple years because of the lower prices. So I can't say this will avoid replant failure, but consider this...we aren't replanting anything this way! Also, the common denominator in replant failure from my observation is tilled/disturbed earth. I think by leaving everything alone in a wild sim patch (meaning the ground is left intact when planting rather than tilled up -which is what my seeder does) and only harvesting single roots, you avoid the whole issue.